Will RSD/CRPS Central Nervous System Pain Soon Be Alleviated?

October 18, 2013 | Posted in , , | 0

RSD/CRPS produces true chronic pain in patients that exceeds all scales of pain measurement due to its effect on their Central Nervous System.

Hope for RSD/CRPS pain relief appears to be close due to research occurring at the UAB School of Medicine, partially funded by a grant from the National Football League. This project has already proceeded to human testing and at the halfway mark continues to display an ability to positively interact with patients Central Nervous System. It is schedule for completion by early Spring with a view towards the medication, delivered via an inhaler or rub on cream, initially used for concussion patients.

With oxidative/nitrosative stress central to parthenogenesis of Central Nervous System  injury, metalloporphyrins offer unique pharmacological activity to improve the course of disease. Metalloporphyrins are efficacious in models of amyotrophic lateral sclerosis, Alzheimer’s disease, epilepsy, neuropathic pain (RSD/CRPS), opioid tolerance, Parkinson’s disease, spinal cord injury, and stroke and have proved to be useful tools in defining roles of superoxide, nitric oxide, and peroxynitrite in disease progression. The most substantive recent advance has been the synthesis of lipophilic metalloporphyrins offering improved blood–brain barrier penetration to allow intravenous, subcutaneous, or oral treatment.

Due to previous failures of “antioxidants” in clinical trials, with most having markedly less biologic activity and bio availability than current-generation metalloporphyrins, a stigma against antioxidants has discouraged the development of metalloporphyrins as CNS therapeutics, despite the consistent definition of efficacy in a wide array of CNS disorders. Future Directions: Further definition of the metalloporphyrin mechanism of action, side-by-side comparison with “failed” antioxidants, and intense effort to optimize therapeutic dosing strategies are required to inform and encourage clinical trial design.

The University of Alabama Birmingham School of Medicine  is currently involved in promising research, which will determine the efficacy of a catalytic oxidoreductant therapeutic to inhibit neuropathic pain  and evaluate important variables about dose and tissue concentration that are crucial for translation to clinical trials. This would benefit all persons who suffer from chronic pain from Central Nervous System disorders.

About Belt Law Firm, P.C.

Belt Law Firm, P.C., is an Alabama law firm with extensive national experience in representing RSD/CRPS afflicted persons and handling RSD/CRPS cases with a focus on regional litigation in Alabama, Tennessee, Georgia, Florida, Arkansas, Mississippi, Texas, New Mexico, Colorado and Delaware. To learn more, call the firm toll-free at 205-933-1500 or use its online form.

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About Belt Law Firm

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The personal injury attorneys at Belt Law Firm have successfully represented RSD/CRPS clients in Alabama, Florida, Georgia, and Tennessee. These cases involved injuries from automobile accidents (shoulder injury, ankle fracture), product malfunctions (hand crush, wrist fracture), slip and falls (knee contusion, wrist fracture), poorly performed blood draws (antecubital pain), and crush injuries (ankle, Achilles tendon).

Among the settlements we have achieved in RSD/CRPS cases are: $2,500,000 for a (AL) slip and fall case involving a woman who developed RSD after suffering a broken wrist, $1,300,000 for a (FL) case where a woman developed RSD after an improperly performed blood draw, and $800,000 for a (TN) woman who developed RSD after suffering a bruised knee due to a slip and fall in a grocery store. ...Read More

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