Siblings Of RSD/CRPS Patients More Prone At Younger Age Due To Genetic Factors

September 18, 2013 | Posted in , , | 0

RSD/CRPS  patients may be at risk of additional complications and accelerating their pain condition, if there is a familial history of RSD/CRPS.

To evaluate whether there were differences between the familial RSD/CRPS and sporadic forms of the syndrome, the clinical characteristics of RSD/CRPS burden of proof were first compared with those of sporadic RSD/CRPS patients from a Dutch population-based study. These patients may be considered representative of the more common type of RSD/CRPS since they were identified inde­pendent of referral. Compared to the sporadic RSD/CRPS patient group, patients with familial RSD/CRPS had a younger age at onset and more often experienced a spontaneous development of RSD/CRPS. Additionally, familial RSD/CRPS patients more frequently had multiple affected extremities and dystonia. . Dystonia seems to be related to a problem in the basal ganglia, which is the area of the brain that is responsible for initiating muscle contractions. The problem involves the way the nerve cells communicate and are classified by the body part they affect:

  • Generalized dystonia affects most of or all of the body.
  • Focal dystonia affects just a specific body part.
  • Multifocal dystonia affects more than one unrelated body part.
  • Segmental dystonia involves adjacent body parts.
  • Hemidystonia affects the arm and leg on the same side of the body.

Compared to the sporadic RSD/CRPS  patients, patients with familial RSD/CRPS were on an average 17 years younger at disease onset, more often had multiple affected extremities, and more often had dystonia.

Additionally familial RSD/CRPS more often had observed temperature asymmetry (lack of proportion between the parts of a thing in the  lack of coordination of two parts acting in connection with one another), color asymmetry, as well as sweating and trophic distur­bances. Plus the median time between onset of RSD/CRPS and examination was much larger for familial RSD/CRPS, which suggests that familial RSD/CRPS patients have a more severe pheno­type (The observable physical and/or biochemical characteristics of the expression of a gene) than sporadic RSD/CRPS patients. All this may point at an increased genetic susceptibility to develop RSD/CRPS.

About Belt Law Firm, P.C.

Belt Law Firm, P.C., is an Alabama law firm with extensive national experience in representing RSD/CRPS afflicted persons and handling RSD/CRPS cases with a focus on regional litigation in Alabama, Tennessee, Georgia, Florida, Arkansas, Mississippi, Texas, New Mexico, Colorado and Delaware. To learn more, call the firm toll-free at 205-933-1500 or use its online form.


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The personal injury attorneys at Belt Law Firm have successfully represented RSD/CRPS clients in Alabama, Florida, Georgia, and Tennessee. These cases involved injuries from automobile accidents (shoulder injury, ankle fracture), product malfunctions (hand crush, wrist fracture), slip and falls (knee contusion, wrist fracture), poorly performed blood draws (antecubital pain), and crush injuries (ankle, Achilles tendon).

Among the settlements we have achieved in RSD/CRPS cases are: $2,500,000 for a (AL) slip and fall case involving a woman who developed RSD after suffering a broken wrist, $1,300,000 for a (FL) case where a woman developed RSD after an improperly performed blood draw, and $800,000 for a (TN) woman who developed RSD after suffering a bruised knee due to a slip and fall in a grocery store. ...Read More

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