Marijuana’s Cannabinoids Aids Nervous Center System Pain Relief

RSD/CRPS patients are constantly searching for innovative treatments and approaches to relieve the high levels of pain their bodies are in motivating modern medicine to continue to look at and research alternative approaches.

Where morphine fails, marijuana may work. That’s the major finding of British research into the pain caused by nerve injuries, a pain known to be somewhat resistant to morphine and similar drugs that are the gold standard for treating just about any other kind of serious pain. The researchers say they now have evidence that active components of cannabis, which is better known as marijuana, may offer hope and have application for mitigating or eliminating pain experienced with RSD/CRPS.

“It’s known that if you injure a nerve, the morphine receptors in the spinal cord disappear and that’s probably why morphine isn’t a very effective pain killer for such conditions as shingles, people who have had an amputation or perhaps if cancer has invaded the spinal cord,” says Dr. Andrew Rice, a senior lecturer in pain research at London’s Imperial College. “But what we’ve shown is that the cannabinoid receptors do not disappear when you injure a nerve. So this could offer a therapeutic advantage over morphine for treating such pain, ” he adds.

Cannabinoids are components of cannabis or compounds that mimic cannabis, and discovering the complexities behind how and why they can offer pain relief has been the focus of various areas of research. Rice says the significance of his team’s research is that they mapped the cannabinoid receptors in the spinal cord and showed that they are found specifically in areas concerned with pain processing.

“Other researchers showed that if you inject cannabinoid compounds in small doses in the spinal cord, you get pain relief. And we showed how that effect is mediated,” he explains. “In addition, a third group of people showed that nerve cells in the spinal cord that are normally activated by pain are damped down by small doses of cannabinoid in the spinal cord fluid.” The findings were published in a recent issue of Molecular and Cellular Neuroscience.

Rice says the task now is to find out how to administer the cannabinoids, but he cautions that the most familiar — smoking it — is the last thing researchers would advise. “Smoking is obviously a big health hazard and we’re certainly not going to advocate that people smoke cannabis. So right now we’re looking at ways of delivering the drug to the body,” he says.”One problem with cannabinoids is that they are very fat-soluble, so that makes them very difficult to formulate the drugs into pills or injections. So one way that’s being looked at by some pharmaceutical companies is using the kind of inhaler that asthma sufferers use. It’s going to be a tough cookie to crack, however,” he adds.

Cannabinoid compounds are among a variety of drugs that have been intensely looked at as researchers look for alternatives to the remarkably few pain relief options. “Researchers have spent the last 30 years trying to understand the mechanism of pain, particularly in the skin and spinal cord, and the massively complex array of chemicals that are involved in that process,” Rice explains. “While people have generally tried to target each of those chemicals to develop pain killers, very few approaches have been successful, and we’re still essentially left with the three very old, basic concepts in drugs: morphine, which has been with us for thousands of years, aspirin or acetaminophen,” he adds.

Dr. Kenneth Mackie, an associate professor in anesthesiology and physiology at the University of Washington in Seattle, says there is indeed great concern in the medical community about the need to find better pain relief for damaged nerves, but that progress is being made. “It’s obviously a big problem for the people who have that kind of pain and on the basic science side, it’s an area of intense investigation. Cannabinoids are just one option that people are looking at. Our understanding of the wiring of the spinal cord is evolving very quickly, however, and we should soon be able to choose drugs to work more effectively,” he adds

About Belt Law Firm, P.C.

Belt Law Firm, P.C., is an Alabama law firm with extensive national experience in representing RSD/CRPS afflicted persons and handling RSD/CRPS cases with a focus on regional litigation in Alabama, Tennessee, Georgia, Florida, Arkansas, Mississippi, Texas, New Mexico, Colorado and Delaware. To learn more, call the firm toll-free at 205-933-1500 or use its online form.


1 Comment

  • edward kinsall says:

    April 30, 2014 at 10:52 am

    I have been a patient of medical marijuana for many years. I have used and developed information with the normal foundation and doctorsof neuroscience & drug additiction to include my primary care doctor who is well versed in these studies through myself. I sufferd extremly with chronic fibromyalgia, arthritis’s , major gout and yesstill fighting the bacterial cancer to include melanoma of the skin and throat. I have studied many years on the use of cannabindoils, cbc,cbg,cba, of course the delta8 & delta 9 thc componants and identified most of all properties than can and are extracted from cannbis sativa, indica, hybrids of all strains. I also had the honor of attending a class the the “Dutchman” “D.J. Short” spoke @ Pasadena college in ca. Found to be very in need to learn how to activate the neurotransmitters from the brain to the cbd receptors. I have evidence in that study that medical marijuana has very effective active compounds. Then very sadly to me after 48yrs in the commerical refrigeration field (HVACR) and the developement of a freon banned in the U.S. Known as “R-12”. I was asked in the yr 2001 highly recommended to Alpine Chemical to help develope a replacement freon safe to the enviroment. Through much R&D we found new properties to use and maintain the dynamics required, that project was finished sold and used by thousands of refrigertion companies in the U.S. I was severly hurt by a freonissue on a large commerical to where a valve blew and saturated my complete left hand and arm with liquid freon (410a) the replacement freon for the old (R-22) freon. The freon froze my hand through the soft tissue, the sub-cantanious tissue, the tendons, ligaments and the nerves and froze the bones. I was also saturated on the left arm with ice that formed to approxitmitly 1/2″ thick while shutting down the liquid freon flow. I have been diagnosed with extreme crps level 3, and now from a syndrome to disease. More medical issue still are very likely to occur over time. My studies with topicals calms nerves

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The personal injury attorneys at Belt Law Firm have successfully represented RSD/CRPS clients in Alabama, Florida, Georgia, and Tennessee. These cases involved injuries from automobile accidents (shoulder injury, ankle fracture), product malfunctions (hand crush, wrist fracture), slip and falls (knee contusion, wrist fracture), poorly performed blood draws (antecubital pain), and crush injuries (ankle, Achilles tendon).

Among the settlements we have achieved in RSD/CRPS cases are: $2,500,000 for a (AL) slip and fall case involving a woman who developed RSD after suffering a broken wrist, $1,300,000 for a (FL) case where a woman developed RSD after an improperly performed blood draw, and $800,000 for a (TN) woman who developed RSD after suffering a bruised knee due to a slip and fall in a grocery store. ...Read More

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